Automatic extraction of sudden death risk markers comining black blood MRI of myocardial scars and artificial intelligence

Sudden cardiac death is one of the most common causes of death worldwide. MRI to characterize it is limited by low 2D resolution and weak blood-scar contrast. The HEARTIFICE project aims to use AI to enable fast, high-resolution 3D MRI acquisitions and automate the segmentation of infarct scars in these images.

Project holder : Aurélien Bustin

Role of the conduction system on repolarization heterogeneity and ventricular fibrillation in a large mammal model of chronic infarction

50-85% of deaths from cardiovascular disease are linked to cardiac rhythm disorders such as ventricular fibrillation (VF). The aim of this research project is to study the different aspects in a pathological model of chronic infarction to improve our understanding of the mechanisms underlying arrhythmogenicity.

Project holder : Marine Martinez

A new method of pacing to prevent the development of ventricular tachyarrhythmias during chronic myocardial infarction

Ventricular arrhythmias are often prevented by cardiac alternants. Recently, a constant diastolic interval (CDI) anti-arrhythmia pacing protocol has been proposed to suppress alternants. This project aims to evaluate the effectiveness of the new constant CDI pacing technology in preventing arrhythmias.

Project holder : Kanchan Kulkani

The main objectives of this project are to use a detailed understanding of the mechanism of sudden cardiac death to identify patients at high risk of sudden cardiac death, and to develop new individualized preventive therapies.

This project has received funding from the "Fondation Leducq" within the framework of the "Transatlantic Networks of Excellence Program" (Research Agreement n°16 CVD 02).

Project holder : Professor Michel Haïssaguerre

Development and validation of a chronic model reproducing a Fontan circulation

One of the most serious congenital heart malformations is the presence of a single ventricle instead of two. The aim of this project is to better understand the mechanisms behind the failures in the treatment of the disease, but also to develop dedicated therapeutic tools.

Project holder : Zacharia Jalal

The main objective of the SOPRANO project is to define the occurrence of micro-structural abnormalities in patients with idiopathic ventricular fibrillation. The project also aims to identify a genetic mutation that may be responsible for electrical and/or structural abnormalities.

Project holder : Doctor Mélèze Hocini

Impact of percutaneous pulmonary valve replacement on ventricular electrophysiological remodelling in repaired tetralogy of fallot.

Tetralogy of Fallot (TF) is the most common cyanotic congenital heart disease. Advances in surgery have increased the survival of TF children, but adults with repaired TF (rTF) have unexplained late complications (arrhythmias). The aim is to study ventricular remodeling in rTF and to assess its reversibility after valve replacement.

Project holder : Jean-Benoît Thambo